|
KMID : 0043319900130030274
|
|
Archives of Pharmacal Research
1990 Volume.13 No. 3 p.274 ~ p.277
|
|
|
Reactions with Activated Nitriles: A new route for the synthesis of new pyridine and pyrazolopyridine derivatives
|
|
Attaby FA
Eldin SM
|
|
|
Abstract
|
|
|
|
It has been found that alpha,beta-unsaturated nitrile derivatives 1-3 reacted with S-methylisothiourea to give the propene derivatives 4-6 respectively. Cyclisation of 4-6 using ethanolic hydrochloric acid afforded the pyridine derivatives 7-9 in good yields. On the other hand, the reactions of hydrazine hydrate and of phenylhydrazine with each of 7-9 gave the corresponding pyrazolopyridine derivatives 10-15. The structures of the newly synthesised derivatives were assigned on the basis of elemental analyses, IR and 1H-NMR spectral data studies.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|